A model for genetic and epigenetic regulatory networks identifies rare for transcription factor induced pluripotency

With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state by ectopic expression of a few transcription factors. An understanding of the mechanisms that underlie data emerging from such experiments can help design optimal strategies for creating pluripotent cells...

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Bibliographic Details
Main Authors: Artyomov, Maxim N., Meissner, Alexander, Chakraborty, Arup K.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/57580
https://orcid.org/0000-0003-1268-9602