Direct cell reprogramming is a stochastic process amenable to acceleration

Direct cell reprogramming is a stochastic process amenable to acceleration

Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) can be achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority of donor somatic cells can be reprogrammed to pluripotency. Here we demonstrate that reprogramming is a conti...

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Bibliographic Details
Main Authors: Jaenisch, Rudolf, Lengner, Christopher J., van Oudenaarden, Alexander, Van Zon, Jeroen Sebastiaan, Pando, Bernardo Fabian, Saha, Krishanu, Hanna, Jacob, Creyghton, Menno P.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2010
Online Access:http://hdl.handle.net/1721.1/58480

Internet

http://hdl.handle.net/1721.1/58480

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