Direct cell reprogramming is a stochastic process amenable to acceleration
Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) can be achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority of donor somatic cells can be reprogrammed to pluripotency. Here we demonstrate that reprogramming is a conti...
Main Authors: | Jaenisch, Rudolf, Lengner, Christopher J., van Oudenaarden, Alexander, Van Zon, Jeroen Sebastiaan, Pando, Bernardo Fabian, Saha, Krishanu, Hanna, Jacob, Creyghton, Menno P. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2010
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Online Access: | http://hdl.handle.net/1721.1/58480 |
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