Improved alignment quality by combining evolutionary information, predicted secondary structure and self-organizing maps

Background Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic trees and protein structure prediction. Numerous studies have shown that the incorporation of predicted secondary structure...

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Bibliographic Details
Main Authors: Ohlson, Tomas, Aggarwal, Varun, Elofsson, Arne, MacCallum, Robert M.
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:English
Published: BioMed Central Ltd 2010
Online Access:http://hdl.handle.net/1721.1/58739