Paradoxical expression of INK4c in proliferative multiple myeloma tumors: bi-allelic deletion vs increased expression

Background: A high proliferative capacity of tumor cells usually is associated with shortened patient survival. Disruption of the RB pathway, which is critically involved in regulating the G1 to S cell cycle transition, is a frequent target of oncogenic events that are thought to contribute to incre...

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Bibliographic Details
Main Authors: Dib, Amel, Raducha-Grace, Laura, Zingone, Adriana, Zhan, Fenghuang, Hanamura, Ichiro, Barlogie, Bart, Shaughnessy, John Jr, Kuehl, W. Michael, Peterson, Timothy Richard
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: BioMed Central Ltd 2010
Online Access:http://hdl.handle.net/1721.1/58873