Computational models with thermodynamic and composition features improve siRNA design

Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large functional genomics projects. Results: To improve the design of efficient siRNA molecules, we performed a comparative, therm...

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Detalhes bibliográficos
Principais autores: Shabalina, Svetlana A., Ogurtsov, Aleksey Y., Spiridonov, Alexey Nikolaevich
Outros Autores: Massachusetts Institute of Technology. Department of Mathematics
Formato: Artigo
Idioma:English
Publicado em: BioMed Central Ltd 2010
Acesso em linha:http://hdl.handle.net/1721.1/58997