Computational models with thermodynamic and composition features improve siRNA design
Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large functional genomics projects. Results: To improve the design of efficient siRNA molecules, we performed a comparative, therm...
Main Authors: | Shabalina, Svetlana A., Ogurtsov, Aleksey Y., Spiridonov, Alexey Nikolaevich |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Mathematics |
Format: | Article |
Language: | English |
Published: |
BioMed Central Ltd
2010
|
Online Access: | http://hdl.handle.net/1721.1/58997 |
Similar Items
-
Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes
by: Shabalina, Svetlana A., et al.
Published: (2012) -
Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design
by: Spiridonov, Alexey Nikolaevich, et al.
Published: (2010) -
Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles
by: Alabi, Christopher A., et al.
Published: (2014) -
FRET-Labeled siRNA Probes for Tracking Assembly and Disassembly of siRNA-Nanocomplexes
by: Alabi, Christopher A., et al.
Published: (2013) -
Small Interference RNA (siRNA)
by: Mohammad Abootaleb, et al.
Published: (2016-08-01)