Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood how different ligands induce different responses and how this is affected by o...

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Bibliographic Details
Main Authors: Lauffenburger, Douglas A., Chen, William W., Schoeberl, Birgit, Jasper, Paul J., Nielsen, Ulrik B., Niepel, Mario, Sorger, Peter K.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2010
Online Access:http://hdl.handle.net/1721.1/60312