The Lack of ADAM17 Activity during Embryonic Development Causes Hemorrhage and Impairs Vessel Formation

Background ADAM17/TACE activity is important during embryonic development. We wished to investigate possible roles of this metalloprotease, focusing on vascular development. Methodology/Principal Findings Mice mutant in the enzymatic activity of ADAM17 were examined at various stages of embry...

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Bibliographic Details
Main Authors: Canault, Matthias, Certel, Kaan, Schatzberg, Daphne, Wagner, Denisa D., Hynes, Richard O
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/60360
https://orcid.org/0000-0001-7603-8396