Mitaplatin, a Potent Fusion of Cisplatin and the Orphan Drug Dichloroacetate
The unique glycolytic metabolism of most solid tumors, known as the Warburg effect, is associated with resistance to apoptosis that enables cancer cells to survive. Dichloroacetate (DCA) is an anticancer agent that can reverse the Warburg effect by inhibiting a key enzyme in cancer cells, pyruvate d...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences
2011
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| Online Access: | http://hdl.handle.net/1721.1/61342 https://orcid.org/0000-0002-2693-4982 |