mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis

Insulin resistance, which is defined as the inability of insulin to promote efficient glucose uptake by peripheral tissues, is a metabolic condition associated with obesity, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Although important advances in our understanding of the molecular...

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Bibliographic Details
Main Authors: Laplante, Mathieu, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences 2011
Online Access:http://hdl.handle.net/1721.1/61405
https://orcid.org/0000-0002-1446-7256