mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis
Insulin resistance, which is defined as the inability of insulin to promote efficient glucose uptake by peripheral tissues, is a metabolic condition associated with obesity, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Although important advances in our understanding of the molecular...
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences
2011
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| Online Access: | http://hdl.handle.net/1721.1/61405 https://orcid.org/0000-0002-1446-7256 |
| _version_ | 1811085483920326656 |
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| author | Laplante, Mathieu Sabatini, David |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Laplante, Mathieu Sabatini, David |
| author_sort | Laplante, Mathieu |
| collection | MIT |
| description | Insulin resistance, which is defined as the inability of insulin to promote efficient glucose uptake by peripheral tissues, is a metabolic condition associated with obesity, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Although important advances in our understanding of the molecular mechanisms involved in the development of insulin resistance have been made during the last decades ( 1), many questions remain. One of these questions relates to the fact that, in the liver of many insulin-resistant mouse models, insulin fails to suppress glucose production (gluconeogenesis) but continues to promote lipid synthesis (lipogenesis) ( 2). This selective hepatic insulin resistance contributes to hyperglycemia and hyperlipidemia and suggests that the insulin-signaling pathway must bifurcate upstream of lipogenesis and gluconeogenesis. In this issue of PNAS, Li et al. ( 3) identify a bifurcation point in the insulin-signaling pathway that could help resolve this important paradox. |
| first_indexed | 2024-09-23T13:10:19Z |
| format | Article |
| id | mit-1721.1/61405 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:10:19Z |
| publishDate | 2011 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/614052022-10-01T13:29:35Z mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis Laplante, Mathieu Sabatini, David Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Koch Institute for Integrative Cancer Research at MIT Sabatini, David M. Sabatini, David M. Laplante, Mathieu Insulin resistance, which is defined as the inability of insulin to promote efficient glucose uptake by peripheral tissues, is a metabolic condition associated with obesity, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Although important advances in our understanding of the molecular mechanisms involved in the development of insulin resistance have been made during the last decades ( 1), many questions remain. One of these questions relates to the fact that, in the liver of many insulin-resistant mouse models, insulin fails to suppress glucose production (gluconeogenesis) but continues to promote lipid synthesis (lipogenesis) ( 2). This selective hepatic insulin resistance contributes to hyperglycemia and hyperlipidemia and suggests that the insulin-signaling pathway must bifurcate upstream of lipogenesis and gluconeogenesis. In this issue of PNAS, Li et al. ( 3) identify a bifurcation point in the insulin-signaling pathway that could help resolve this important paradox. National Institutes of Health (U.S.) Howard Hughes Medical Institute Canadian Institutes of Health Research 2011-03-04T15:39:43Z 2011-03-04T15:39:43Z 2010-02 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/61405 Laplante, Mathieu, and David M. Sabatini. “mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.” Proceedings of the National Academy of Sciences 107.8 (2010): 3281 -3282. ©2010 by the National Academy of Sciences. https://orcid.org/0000-0002-1446-7256 en_US http://dx.doi.org/10.1073/pnas.1000323107 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences PNAS |
| spellingShingle | Laplante, Mathieu Sabatini, David mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis |
| title | mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis |
| title_full | mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis |
| title_fullStr | mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis |
| title_full_unstemmed | mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis |
| title_short | mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis |
| title_sort | mtorc1 activates srebp 1c and uncouples lipogenesis from gluconeogenesis |
| url | http://hdl.handle.net/1721.1/61405 https://orcid.org/0000-0002-1446-7256 |
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