Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways
Two-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental stimuli. Sensor histidine kinases transmit signals to their cognate response regulators via phosphorylation. The faithful transmission of information through two-component pathways and the...
Main Authors: | Capra, Emily Jordan, Perchuk, Barrett, Lubin, Emma Alexandra, Ashenberg, Orr, Skerker, Jeffrey M., Laub, Michael T |
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Other Authors: | Massachusetts Institute of Technology. Computational and Systems Biology Program |
Format: | Article |
Language: | en_US |
Published: |
Public Library of Science
2011
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Online Access: | http://hdl.handle.net/1721.1/64739 https://orcid.org/0000-0002-8288-7607 |
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