Transcription Inhibition by Platinum DNA Cross-links in Live Mammalian Cells

We have investigated the processing of site-specific Pt−DNA cross-links in live mammalian cells to enhance our understanding of the mechanism of action of platinum-based anticancer drugs. The activity of platinum drugs against cancer is mediated by a combination of processes including cell entry, dr...

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Bibliográfalaš dieđut
Váldodahkkit: Ang, Wee Han, Myint, MyatNoeZin, Lippard, Stephen J.
Eará dahkkit: Massachusetts Institute of Technology. Department of Chemistry
Materiálatiipa: Artihkal
Giella:en_US
Almmustuhtton: American Chemical Society 2011
Liŋkkat:http://hdl.handle.net/1721.1/64756
https://orcid.org/0000-0002-2693-4982