Transcription Inhibition by Platinum DNA Cross-links in Live Mammalian Cells
We have investigated the processing of site-specific Pt−DNA cross-links in live mammalian cells to enhance our understanding of the mechanism of action of platinum-based anticancer drugs. The activity of platinum drugs against cancer is mediated by a combination of processes including cell entry, dr...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society
2011
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| Online Access: | http://hdl.handle.net/1721.1/64756 https://orcid.org/0000-0002-2693-4982 |