3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1

Studies of long-lived Caenorhabditis elegans mutants have identified several genes that function to limit lifespan, i.e., loss-of-function mutations in these genes promote longevity. By contrast, little is known about genes that normally act to delay aging and that when mutated cause premature a...

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Bibliographic Details
Main Authors: Berdichevsky, Alina, Nedelcu, Simona, Boulias, Konstantinos, Bishop, Nicholas A., Guarente, Leonard Pershing, Horvitz, Howard Robert
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences 2011
Online Access:http://hdl.handle.net/1721.1/64811
https://orcid.org/0000-0002-9964-9613
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0002-5117-3994