3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1
Studies of long-lived Caenorhabditis elegans mutants have identified several genes that function to limit lifespan, i.e., loss-of-function mutations in these genes promote longevity. By contrast, little is known about genes that normally act to delay aging and that when mutated cause premature a...
Main Authors: | Berdichevsky, Alina, Nedelcu, Simona, Boulias, Konstantinos, Bishop, Nicholas A., Guarente, Leonard Pershing, Horvitz, Howard Robert |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences
2011
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Online Access: | http://hdl.handle.net/1721.1/64811 https://orcid.org/0000-0002-9964-9613 https://orcid.org/0000-0003-4064-2510 https://orcid.org/0000-0002-5117-3994 |
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