Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness
Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that pro...
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences
2011
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| Online Access: | http://hdl.handle.net/1721.1/64815 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 |
| _version_ | 1826213777035493376 |
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| author | Ching, Shinung Cimenser, Aylin Purdon, Patrick Lee Brown, Emery N. Kopell, Nancy J. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Ching, Shinung Cimenser, Aylin Purdon, Patrick Lee Brown, Emery N. Kopell, Nancy J. |
| author_sort | Ching, Shinung |
| collection | MIT |
| description | Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity [alpha activity]. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state. |
| first_indexed | 2024-09-23T15:54:38Z |
| format | Article |
| id | mit-1721.1/64815 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:54:38Z |
| publishDate | 2011 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/648152022-10-02T04:58:38Z Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness Ching, Shinung Cimenser, Aylin Purdon, Patrick Lee Brown, Emery N. Kopell, Nancy J. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Brown, Emery N. Ching, Shinung Cimenser, Aylin Purdon, Patrick Lee Brown, Emery N. Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity [alpha activity]. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state. National Institutes of Health (U.S.) (Grant DP1-OD003646) National Institutes of Health (U.S.) (Grant K25-NS057580) National Institutes of Health (U.S.) (Grant DP2-OD006454) National Science Foundation (U.S.) (Grant DMS-0717670) 2011-07-14T20:31:37Z 2011-07-14T20:31:37Z 2010-12 2010-08 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/64815 Ching, S. et al. “Thalamocortical Model for a Propofol-induced -rhythm Associated with Loss of Consciousness.” Proceedings of the National Academy of Sciences 107.52 (2010) : 22665-22670. https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 en_US http://dx.doi.org/10.1073/pnas.1017069108 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences PNAS |
| spellingShingle | Ching, Shinung Cimenser, Aylin Purdon, Patrick Lee Brown, Emery N. Kopell, Nancy J. Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness |
| title | Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness |
| title_full | Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness |
| title_fullStr | Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness |
| title_full_unstemmed | Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness |
| title_short | Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness |
| title_sort | thalamocortical model for a propofol induced alpha rhythm associated with loss of consciousness |
| url | http://hdl.handle.net/1721.1/64815 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 |
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