A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly precise mass spectrometric method to quantify...

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Bibliographic Details
Main Authors: Chan, Tsz Yan Clement, Dyavaiah, Madhu, DeMott, Michael S., Taghizadeh, Koli, Dedon, Peter C., Begley, Thomas J.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/64964
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-7940-3459
https://orcid.org/0000-0002-4607-5337

Internet

http://hdl.handle.net/1721.1/64964
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-7940-3459
https://orcid.org/0000-0002-4607-5337

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