Effect of photobleaching on calibration model development in biological Raman spectroscopy

A major challenge in performing quantitative biological studies using Raman spectroscopy lies in overcoming the influence of the dominant sample fluorescence background. Moreover, the prediction accuracy of a calibration model can be severely compromised by the quenching of the endogenous fluorophor...

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Detalhes bibliográficos
Principais autores: Barman, Ishan, Kong, Chae-Ryon, Singh, Gajendra P., Dasari, Ramachandra Rao
Outros Autores: Massachusetts Institute of Technology. Laser Biomedical Research Center
Formato: Artigo
Idioma:en_US
Publicado em: Society of Photo-optical Instrumentation Engineers (SPIE) 2011
Acesso em linha:http://hdl.handle.net/1721.1/64970