MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

Many human aneuploidy syndromes have unique phenotypic consequences, but in most instances it is unclear whether these phenotypes are attributable to alterations in the dosage of specific genes. In human trisomy 13, there is delayed switching and persistence of fetal hemoglobin (HbF) and elevation o...

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Bibliographic Details
Main Authors: Sankaran, Vijay G., Menne, Tobias F., Scepanovic, Danilo, Vergilio, Jo-Anne, Ji, Peng, Kim, Jinkuk, Thiru, Prathapan, Orkin, Stuart H., Lander, Eric Steven, Lodish, Harvey F
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2011
Online Access:http://hdl.handle.net/1721.1/65156
https://orcid.org/0000-0002-7029-7415

Internet

http://hdl.handle.net/1721.1/65156
https://orcid.org/0000-0002-7029-7415

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