Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

Ubiquitin-dependent processes control much of cellular physiology. We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating enzyme (EBV-DUB) blocks proteasomal degradation of cytosolic and ER-derived proteins by preemptive removal of ubiquitin from proteasome substrate...

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Bibliographic Details
Main Authors: Ernst, Robert, Claessen, Jasper H. L., Mueller, Britta, Sanyal, Sumana, Spooner, Eric, van der Veen, Annemarthe G., Kirak, Oktay, Schlieker, Christian D., Weihofen, Wilhelm A., Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/65337
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/65337
https://orcid.org/0000-0002-1090-6071

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