VX Hydrolysis by Human Serum Paraoxonase 1: A Comparison of Experimental and Computational Results

VX Hydrolysis by Human Serum Paraoxonase 1: A Comparison of Experimental and Computational Results

Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it has been suggested that increasing HuPON1's org...

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Bibliographic Details
Main Authors: Peterson, Matthew W., Fairchild, Steven Z., Otto, Tamara C., Mohtashemi, Mojdeh, Cerasoli, Douglas M., Chang, Wenling E.
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/65397

Internet

http://hdl.handle.net/1721.1/65397

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