Effect of Nanoparticle Conjugation on Gene Silencing by RNA Interference

RNA interference (RNAi) is a cellular process whereby the silencing of a particular gene is mediated by short RNAs (siRNAs). Although siRNAs have great therapeutic potential, cellular delivery has been a challenge. Nanoparticle-siRNA conjugates have emerged as potential delivery vehicles; however, r...

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Bibliographic Details
Main Authors: Singh, Neetu, Agrawal, Amit, Leung, Anthony, Sharp, Phillip A., Bhatia, Sangeeta N.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: American Chemical Society 2011
Online Access:http://hdl.handle.net/1721.1/65573
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0002-1293-2097