Rag proteins regulate amino-acid-induced mTORC1 signalling

The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPa...

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Bibliographic Details
Main Authors: Sancak, Yasemin, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Biomedical Society 2011
Online Access:http://hdl.handle.net/1721.1/65577
https://orcid.org/0000-0002-1446-7256