Rag proteins regulate amino-acid-induced mTORC1 signalling
The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPa...
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| Format: | Article |
| Language: | en_US |
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Biomedical Society
2011
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| Online Access: | http://hdl.handle.net/1721.1/65577 https://orcid.org/0000-0002-1446-7256 |
| _version_ | 1811069905936580608 |
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| author | Sancak, Yasemin Sabatini, David |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sancak, Yasemin Sabatini, David |
| author_sort | Sancak, Yasemin |
| collection | MIT |
| description | The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPase) family of GTPases as mediators of amino acid signalling to mTOR is an important step towards our understanding of this mechanism. |
| first_indexed | 2024-09-23T08:18:50Z |
| format | Article |
| id | mit-1721.1/65577 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:18:50Z |
| publishDate | 2011 |
| publisher | Biomedical Society |
| record_format | dspace |
| spelling | mit-1721.1/655772022-09-30T08:57:24Z Rag proteins regulate amino-acid-induced mTORC1 signalling Sancak, Yasemin Sabatini, David Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Koch Institute for Integrative Cancer Research at MIT Sabatini, David M. Sabatini, David M. Sancak, Yasemin The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPase) family of GTPases as mediators of amino acid signalling to mTOR is an important step towards our understanding of this mechanism. National Institutes of Health (U.S.) (R01 CA103866) National Institutes of Health (U.S.) (AI47389) United States. Dept. of Defense (grant number W81XWH-07-0448) W. M. Keck Foundation 2011-08-31T19:25:14Z 2011-08-31T19:25:14Z 2009-01 2008-09 Article http://purl.org/eprint/type/JournalArticle 0300-5127 http://hdl.handle.net/1721.1/65577 Sancak, Yasemin, and David M. Sabatini. “Rag Proteins Regulate Amino-acid-induced mTORC1 Signalling.” Biochemical Society Transactions 37.1 (2009) : 289-290. https://orcid.org/0000-0002-1446-7256 en_US http://dx.doi.org/10.1042/bst0370289 Biochemical Society Transactions Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Biomedical Society Portland Press |
| spellingShingle | Sancak, Yasemin Sabatini, David Rag proteins regulate amino-acid-induced mTORC1 signalling |
| title | Rag proteins regulate amino-acid-induced mTORC1 signalling |
| title_full | Rag proteins regulate amino-acid-induced mTORC1 signalling |
| title_fullStr | Rag proteins regulate amino-acid-induced mTORC1 signalling |
| title_full_unstemmed | Rag proteins regulate amino-acid-induced mTORC1 signalling |
| title_short | Rag proteins regulate amino-acid-induced mTORC1 signalling |
| title_sort | rag proteins regulate amino acid induced mtorc1 signalling |
| url | http://hdl.handle.net/1721.1/65577 https://orcid.org/0000-0002-1446-7256 |
| work_keys_str_mv | AT sancakyasemin ragproteinsregulateaminoacidinducedmtorc1signalling AT sabatinidavid ragproteinsregulateaminoacidinducedmtorc1signalling |