Sortase-catalyzed transformations that improve the properties of cytokines
Recombinant protein therapeutics often suffer from short circulating half-life and poor stability, necessitating multiple injections and resulting in limited shelf-life. Conjugation to polyethylene glycol chains (PEG) extends the circulatory half-life of many proteins, but the methods for attachment...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2011
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| Online Access: | http://hdl.handle.net/1721.1/65875 https://orcid.org/0000-0002-1090-6071 |