Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes

Prions are self-perpetuating aggregated proteins that are not limited to mammalian systems but also exist in lower eukaryotes including yeast. While much work has focused around chaperones involved in prion maintenance, including Hsp104, little is known about factors involved in the appearance of pr...

Full description

Bibliographic Details
Main Authors: Manogaran, Anita L., Hong, Joo Y., Hufana, Joan, Tyedmers, Jens, Lindquist, Susan, Liebman, Susan W.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/66126
https://orcid.org/0000-0003-1307-882X