Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli

Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli

Predictive understanding of cell signaling network operation based on general prior knowledge but consistent with empirical data in a specific environmental context is a current challenge in computational biology. Recent work has demonstrated that Boolean logic can be used to create context-specific...

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Bibliographic Details
Main Authors: Morris, Melody Kay, Saez-Rodriguez, Julio, Clarke, David C., Sorger, Peter K., Lauffenburger, Douglas A.
Other Authors: Massachusetts Institute of Technology. Cell Decision Process Center
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/66218

Internet

http://hdl.handle.net/1721.1/66218

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