Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis

It is well accepted that cancer develops following the sequential accumulation of multiple alterations, but how the temporal order of events affects tumor initiation and/or progression remains largely unknown. Here, we describe a mouse model that allows for temporally distinct cancer mutations. By i...

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Bibliográfalaš dieđut
Váldodahkkit: Young, Nathan P., Crowley, Denise G., Jacks, Tyler E
Eará dahkkit: Massachusetts Institute of Technology. Department of Biology
Materiálatiipa: Artihkal
Giella:en_US
Almmustuhtton: American Association for Cancer Research 2011
Liŋkkat:http://hdl.handle.net/1721.1/66517
https://orcid.org/0000-0001-5785-8911