Potent inhibition of cartilage biosynthesis by coincubation with joint capsule through an IL-1-independent pathway
The reason for the increased risk for development of osteoarthritis (OA) after acute joint trauma is not well understood, but the mechanically injured cartilage may be more susceptible to degradative mediators secreted by other tissues in the joint. To establish a model for such interactions, we coi...
Main Authors: | Grodzinsky, Alan J., Patwari, P., Lin, S. N., Kurz, Bodo, Cole, Ada A., Kumar, S. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Center for Biomedical Engineering |
Format: | Article |
Language: | en_US |
Published: |
John Wiley & Sons, Inc.
2011
|
Online Access: | http://hdl.handle.net/1721.1/66583 https://orcid.org/0000-0002-4942-3456 |
Similar Items
-
Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation
by: Kar, Saptarshi, et al.
Published: (2017) -
Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity
by: Swärd, Per, et al.
Published: (2017) -
Effects of joint capsule tissue on cartilage degradation in an in vitro joint injury model
by: Lin, Stephanie Norris, 1980-
Published: (2006) -
Vulnerability of the superficial zone of immature articular cartilage to compressive injury
by: Rolauffs, Bernd, et al.
Published: (2011) -
Mannosamine inhibits aggrecanase-mediated degradation of the mechanically functional portion of proteoglycans and of the physical properties of articular cartilage
by: Patwari, Parth, 1972-
Published: (2014)