The Molecular Origin and Consequences of Escape from miRNA Regulation by HLA-C Alleles

The Molecular Origin and Consequences of Escape from miRNA Regulation by HLA-C Alleles

Differential expression of human leukocyte antigen C (HLA-C) allotypes is mediated by the binding of a microRNA, miR-148a, to the 3′ untranslated region of some, but not all, HLA-C alleles. The binding results in lower levels of HLA-C expression, which is associated with higher levels of HIV-1 viral...

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Bibliographic Details
Main Authors: O'hUigin, Colm, Kulkarni, Smita, Xu, Yunping, Deng, Zhihui, Kidd, Judith, Kidd, Kenneth, Gao, Xiaojiang, Carrington, Mary
Other Authors: Ragon Institute of MGH, MIT and Harvard
Format: Article
Language:en_US
Published: Elsevier B.V. 2011
Online Access:http://hdl.handle.net/1721.1/66696

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http://hdl.handle.net/1721.1/66696

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