Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Due to its common dysregulation in epithelial-based cancers and extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) is a highly validated target for anticancer therapies. There has been particular interest in the development of monoclonal antibodies (mAbs)...

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Bibliographic Details
Main Authors: Spangler, Jamie Berta, Neil, Jason Robert, Abramovitch, Sivan, Yarden, Yosef, White, Forest M., Lauffenburger, Douglas A., Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2011
Online Access:http://hdl.handle.net/1721.1/66709
https://orcid.org/0000-0002-1545-1651
https://orcid.org/0000-0003-2398-5896

Internet

http://hdl.handle.net/1721.1/66709
https://orcid.org/0000-0002-1545-1651
https://orcid.org/0000-0003-2398-5896

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