Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG)

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG)

The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N[superscript 6]-ethenoadenine (εA). The crystal structures of AAG bound to εA have provide...

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Bibliographic Details
Main Authors: Lee, Chun-Yue I., Delaney, James C., Kartalou, Maria, Lingaraju, Gondichatnahalli M., Maor-Shoshani, Ayelet, Essigmann, John M., Samson, Leona D
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Chemical Society 2011
Online Access:http://hdl.handle.net/1721.1/66891
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-2196-5691
https://orcid.org/0000-0002-7112-1454

Internet

http://hdl.handle.net/1721.1/66891
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-2196-5691
https://orcid.org/0000-0002-7112-1454

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