Both base excision repair and O-6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

Both base excision repair and O-6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

Methylating agents are widely distributed environmental carcinogens. Moreover, they are being used in cancer chemotherapy. The primary target of methylating agents is DNA, and therefore, DNA repair is the first-line barrier in defense against their toxic and carcinogenic effects. Methylating agents...

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Bibliographic Details
Main Authors: Samson, Leona D., Wirtz, Stefan, Nagel, Georg, Eshkind, Leonid, Neurath, Markus F., Kaina, Bernd
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: Oxford University Press 2011
Online Access:http://hdl.handle.net/1721.1/66892
https://orcid.org/0000-0002-7112-1454

Internet

http://hdl.handle.net/1721.1/66892
https://orcid.org/0000-0002-7112-1454

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