Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

tRNA nucleosides are extensively modified to ensure their proper function in translation. However, many of the enzymes responsible for tRNA modifications in mammals await identification. Here, we show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridi...

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Bibliographic Details
Main Authors: Fu, Dragony, Brophy, Jennifer Ann, Atmore, Kyle Aaquil, Begley, Ulrike, Begley, Thomas J., Paules, Richard S., Chan, Clement T. Y., Dedon, Peter C, Samson, Leona D
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Society for Microbiology 2011
Online Access:http://hdl.handle.net/1721.1/66893
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-7808-4281
https://orcid.org/0000-0001-7940-3459
https://orcid.org/0000-0002-7112-1454

Internet

http://hdl.handle.net/1721.1/66893
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-7808-4281
https://orcid.org/0000-0001-7940-3459
https://orcid.org/0000-0002-7112-1454

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