GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

We describe methods with enhanced power and specificity to identify genes targeted by somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA profiles into underlying arm-level and focal alterations, we improve the estimation of background rates for each category. We add...

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Bibliographic Details
Main Authors: Mermel, Craig H., Schumacher, Steven E., Hill, Barbara, Meyerson, Matthew L., Beroukhim, Rameen, Getz, Gad
Other Authors: Whitaker College of Health Sciences and Technology
Format: Article
Language:en_US
Published: BioMed Central Ltd. 2011
Online Access:http://hdl.handle.net/1721.1/66962

Internet

http://hdl.handle.net/1721.1/66962

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