Combined logical and data-driven models for linking signalling pathways to cellular response

Background Signalling pathways are the cornerstone on understanding cell function and predicting cell behavior. Recently, logical models of canonical pathways have been optimised with high-throughput phosphoproteomic data to construct cell-type specific pathways. However, less is known on how sig...

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Bibliographic Details
Main Authors: Melas, Ioannis N., Mitsos, Alexander, Messinis, Dimitris E., Weiss, Thomas S., Alexopoulos, Leonidas G.
Other Authors: Massachusetts Institute of Technology. Department of Mechanical Engineering
Format: Article
Language:en_US
Published: BioMed Central Ltd. 2011
Online Access:http://hdl.handle.net/1721.1/66963