Solution Structure of the Zbeta Domain of Human DAI and Its Binding Modes to B-  and Z-DNAs

Solution Structure of the Zbeta Domain of Human DAI and Its Binding Modes to B-  and Z-DNAs

The DNA-dependent activator of IFN-regulatory factors (DAI), also known as DLM-1/ZBP1, initiates an innate immune response by binding to foreign DNAs in the cytosol. For full activation of the immune response, three DNA binding domains at the N terminus are required: two Z-DNA binding domains (ZBDs)...

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Bibliographic Details
Main Authors: Kim, Kyungmin, Khayrutdinov, Bulat I., Lee, Chung-Kyung, Cheong, Hae-Kap, Kang, Sung Wook, Park, Hyejin, Lee, Sangho, Kim, Yang-Gyun, Jee, JunGoo, Rich, Alexander, Kim, Kyeong Kyu, Jeon, Young Ho
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2011
Online Access:http://hdl.handle.net/1721.1/66977

Internet

http://hdl.handle.net/1721.1/66977

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