Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin

Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin

ERK activation is enhanced by the scaffolding proteins KSR and MP1, localized near the cell membrane and late endosomes respectively, but little is known about their dynamic interplay. We develop here a mathematical model with ordinary differential equations to describe the dynamic activation of EGF...

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Bibliographic Details
Main Authors: Huang, Lu, Pan, Catherine Qiurong, Li, Baowen, Tucker-Kellogg, Lisa, Tidor, Bruce, Chen, Yu Zong, Low, Boon Chuan
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/66997
https://orcid.org/0000-0002-3320-3969

Internet

http://hdl.handle.net/1721.1/66997
https://orcid.org/0000-0002-3320-3969

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