Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

Multitarget compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms of a particular combination of relatively more spec...

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Bibliographic Details
Main Authors: Wands, Jack R., Cosgrove, Benjamin D., Hemann, Michael, Pritchard, Justin R., Griffith, Linda G, Lauffenburger, Douglas A
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Association for Cancer Research 2011
Online Access:http://hdl.handle.net/1721.1/67045
https://orcid.org/0000-0002-1801-5548