Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death
Multitarget compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms of a particular combination of relatively more spec...
Main Authors: | Wands, Jack R., Cosgrove, Benjamin D., Hemann, Michael, Pritchard, Justin R., Griffith, Linda G, Lauffenburger, Douglas A |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
American Association for Cancer Research
2011
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Online Access: | http://hdl.handle.net/1721.1/67045 https://orcid.org/0000-0002-1801-5548 |
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