Quantification of the 2-Deoxyribonolactone and Nucleoside 5 '-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of gamma-Radiation and Fe[superscript 2+]-EDTA

Quantification of the 2-Deoxyribonolactone and Nucleoside 5 '-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of gamma-Radiation and Fe[superscript 2+]-EDTA

The oxidation of 2-deoxyribose in DNA has emerged as a critical determinant of the cellular toxicity of oxidative damage to DNA, with oxidation of each carbon producing a unique spectrum of electrophilic products. We have developed and validated an isotope-dilution gas chromatography-coupled mass sp...

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Bibliographic Details
Main Authors: Chan, Wan Simon, Chen, Bingzi, Wang, Lianrong, Taghizadeh, Koli, Demott, Michael S., Dedon, Peter C.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Chemical Society 2011
Online Access:http://hdl.handle.net/1721.1/67256
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0002-4607-5337

Internet

http://hdl.handle.net/1721.1/67256
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0002-4607-5337

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