Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons

Recombinant rabies viruses rendered replication-deficient by the deletion of their envelope glycoprotein gene are useful tools for neuroscientists, permitting (1) extraordinarily high transgene expression levels within neurons, (2) retrograde infection of projection neurons through their axon termin...

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Bibliographic Details
Main Authors: Wickersham, Ian R., Sullivan, Heather, Seung, H. Sebastian
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Nature Publishing Group 2011
Online Access:http://hdl.handle.net/1721.1/67322