Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK

Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK

The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene represents a molecular target in a small subset of non-small cell lung cancers (NSCLCs). This fusion leads to constitutive ALK activation with potent transforming activity. In a pivotal phase...

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Bibliographic Details
Main Authors: Katayama, Ryohei, Benes, Cyril H., Lifshits, Eugene, Ebi, Hiromichi, Rivera, Victor M., Shakespeare, William C., Iafrate, A. John, Engelman, Jeffrey A., Shaw, Alice
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: National Academy of Sciences 2011
Online Access:http://hdl.handle.net/1721.1/67357

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http://hdl.handle.net/1721.1/67357

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