Structure of the EGF receptor transactivation circuit integrates with cell context

Transactivation of the epidermal growth factor receptor (EGFR) is thought to be a process by which a variety of cellular inputs can be integrated into a single signaling pathway through either stimulated proteolysis (shedding) of membrane-anchored EGFR ligands or by modification of the activity of t...

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Príomhchruthaitheoirí: Joslin, Elizabeth J., Shankaran, Harish, Opresko, Lee K., Bollinger, Nikki, Lauffenburger, Douglas A., Wiley, H. Steven
Rannpháirtithe: Massachusetts Institute of Technology. Department of Biological Engineering
Formáid: Alt
Teanga:en_US
Foilsithe / Cruthaithe: Royal Society of Chemistry 2012
Rochtain ar líne:http://hdl.handle.net/1721.1/68646