Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity
The HDL receptor, scavenger receptor, class B, type I (SR-BI), is a homooligomeric cell surface glycoprotein that controls HDL structure and metabolism by mediating the cellular selective uptake of lipids, mainly cholesteryl esters, from HDL. The mechanism underlying SR-BI-mediated lipid transfer, w...
Main Authors: | Saenz-Vash, Veronica, Romer, Katherine A., Xu, Shangzhe, Yesilaltay, Ayce, Krieger, Monty, Yu, Miao, Nieland, Thomas J, Penman, Marsha L, Carr, Steven A |
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Other Authors: | Massachusetts Institute of Technology. Computational and Systems Biology Program |
Format: | Article |
Language: | en_US |
Published: |
Proceedings of the National Academy of Sciences (PNAS)
2012
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Online Access: | http://hdl.handle.net/1721.1/69003 https://orcid.org/0000-0003-4541-5181 https://orcid.org/0000-0003-2673-1672 https://orcid.org/0000-0002-7203-4299 https://orcid.org/0000-0002-5503-182X https://orcid.org/0000-0001-9905-5316 |
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