Coordinate linkage of HIV evolution reveals regions of immunological vulnerability
Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations o...
| Main Authors: | , , , , , , , , , , , |
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| 其他作者: | |
| 格式: | 文件 |
| 语言: | en_US |
| 出版: |
Proceedings of the National Academy of Sciences (PNAS)
2012
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| 在线阅读: | http://hdl.handle.net/1721.1/69005 https://orcid.org/0000-0003-1268-9602 |