Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations o...

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Bibliographic Details
Main Authors: Pereyra, Florencia, Miura, Toshiyuki, Allen, Todd M., Altfeld, Marcus, Carrington, Mary, Walker, Bruce D., Dahirel, Vincent, Shekhar, Karthik, Artyomov, Mikita, Talsania, Shiv, Irvine, Darrell J., Chakraborty, Arup K.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Proceedings of the National Academy of Sciences (PNAS) 2012
Online Access:http://hdl.handle.net/1721.1/69005
https://orcid.org/0000-0003-1268-9602

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http://hdl.handle.net/1721.1/69005
https://orcid.org/0000-0003-1268-9602

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