Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner
Whereas the roles of proangiogenic factors in carcinogenesis are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elaborated. We investigated the roles of three EAIs during de novo tumorigenesis to further test the angiogenic balance hypothesis, which suggests...
Main Authors: | Xie, Liang, Duncan, Michael B., Pahler, Jessica, Sugimoto, Hikaru, Martino, Margot, Lively, Julie, Mundel, Thomas, Soubasakos, Mary, Takeda, Takaaki, Inoue, Masahiro, Lawler, Jack, Hanahan, Douglas, Rubin, Kristofer, Kalluri, Raghu, Hynes, Richard O |
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Other Authors: | Harvard University--MIT Division of Health Sciences and Technology |
Format: | Article |
Language: | en_US |
Published: |
Proceedings of the National Academy of Sciences (PNAS)
2012
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Online Access: | http://hdl.handle.net/1721.1/69020 https://orcid.org/0000-0001-7603-8396 |
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