Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway

Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of...

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Main Authors: Zhu, J. Julius, Clauser, Karl R., Guan, Ji-Song, Gao, Jun, Xie, Zhigang, Zhou, Ying, Durak, Omer, Tsai, Li-Huei, Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014., Carr, Steven A, Su, S., Joseph, Nadine F.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Public Library of Science 2012
Online Access:http://hdl.handle.net/1721.1/69083
https://orcid.org/0000-0002-7203-4299
https://orcid.org/0000-0003-1262-0592
https://orcid.org/0000-0001-8426-6188